|2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-三羟基-10,13-二甲基十六氢-1H-环戊[a]菲-17-基)戊酰胺)乙烷-1-磺酸钠 (1:1)|CsnPharm

CAS No.: 145-42-6

Synonyms: Sodium taurocholate;N-Choloyltaurine sodium;Taurocholic Acid (sodium salt)

Monosodium taurocholate is an agonist of GPBAR1 and is potential of the treatment of type 2 diabetes and obesity in rats.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述Monosodium Taurocholate is a bile salt. It contains a taurocholate and is a Na(+)-dependent taurocholate. Taurocholate is a natural conjugated bile acid. Compared with the model group, treatment with taurocholate (20, 40 and 60mg/kg) significantly inhibited the body weight loss, improved colonic weight and length, and decreased macroscopic and histopathological scores. Furthermore, the activity accumulation of MPO and the colonic tissue levels of IL-1β, IFN-γ and TNF-α were also decreased by administration of taurocholate^[1]. The absorption of cefquinome in Caco-2 cell monolayers was significantly increased with the sodium taurocholate (2mM)^[2]. The Na(+)-dependent taurocholate transport showed saturation kinetics and the phenomenon of counterflow were inhibited by glycocholate^[3]. The addition of 20 mM taurocholate caused transient but significant depolarization accompanied by a significant decrease in membrane resistance. The electrical effect induced by taurocholate mimicked that induced by L-alanine (10 mM), the uptake of which is known to occur through an electrogenic, sodium-coupled mechanism^[4].
参考文献

实验方案

技术信息

CAS号	145-42-6	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C26H44NNaO7S	运输	蓝冰
分子量	537.68	别名	Sodium taurocholate;N-Choloyltaurine sodium;Taurocholic Acid (sodium salt);Ethanesulfonic Acid;TCA;牛磺胆酸钠

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户